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Allele : Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky> gene trap ROSA 26, Philippe Soriano; targeted mutation 8, Klaus Rajewsky
Primary Identifier  MGI:4430550 Allele Type  Targeted
Attribute String  Conditional ready, Constitutively active, Inserted expressed sequence, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  A targeting vector designed with (from 5' to 3') a splice acceptor site, a loxP-flanked Neo-STOP cassette, a cDNA sequence encoding rat MEK1DD (a mutant form of MAPKK1 rendered constitutively active by two serine to aspartic acid substitutions (S218D/S222D) within the catalytic domain], an FRT-flanked internal ribosomal entry site-enhanced green fluorescent protein cassette (IRES-EGFP), and bovine polyadenylation signal. This transgene construct was inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus.
  • mutations:
  • Insertion
  • synonyms:
  • R26Stop flox MEK1DD,
  • R26Stop<FL>MEK1DD,
  • R26Stop-flox-MEK1DD,
  • ROSA<MEK1*>,
  • R26Stop-flox-MEK1DD,
  • MEk1DD,
  • R26Stop<FL>MEK1DD,
  • ROSA<MEK1*>,
  • MEk1DD,
  • R26Stop flox MEK1DD
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

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0 Driven By

37 Publication categories

Trail: Allele




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