| Primary Identifier | MGI:4437607 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inducible, Inserted expressed sequence, Reporter | Gene | Hprt1 |
| Transmission | Germline | Strain of Origin | 129 and C57BL/6 |
| Induced With | doxycycline/tetracycline | Is Recombinase | false |
| Is Wild Type | false |
| description | ES cell line = BPES11 (carries Hprtb-m3). This cell line was established from Hprt mutant mice on a highly mixed C57BL/6 and 129 background that had been derived from ES cell line BK4 (129P2/OlaHsd). |
| molecularNote | A transgene containing a bidirectional tetracycline promoter (tetO) driving expression of human lacZ (5' of tetO) and GR1 (3' of tetO) was inserted into the locus by homologous recombination. Selection was achieved by restoring the locus that is defective in the ES cells used to generate this allele. Following activation of tetO, both GR1 and lacZ expression is detected. |
