| Primary Identifier | MGI:4436726 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Ush1c |
| Transmission | Germline | Strain of Origin | 129S/SvEv-Gpi1<c> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A GLG motif was mutated to AAA in the PDZ2 domain, within exon 8, in addition an FRT flanked neo cassette was inserted in intron 6 by homologous recombination. The neo cassette was removed by flp mediated recombination. This mutation is predicted to disrupt protein interactions with CDH23. Whole mount analysis revealed mislocalization of the mutant protein (widely distributed) in cochlear stereocilia from homozygous mice. |
