| First Author | Kashiwada M | Year | 2011 |
| Journal | EMBO J | Volume | 30 |
| Issue | 10 | Pages | 2071-82 |
| PubMed ID | 21499227 | Mgi Jnum | J:172055 |
| Mgi Id | MGI:5003376 | Doi | 10.1038/emboj.2011.111 |
| Citation | Kashiwada M, et al. (2011) NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. EMBO J 30(10):2071-82 |
| abstractText | Type 2 T helper (T(H)2) cells are critical for the development of allergic immune responses; however, the molecular mechanism controlling their effector function is still largely unclear. Here, we report that the transcription factor NFIL3/E4BP4 regulates cytokine production and effector function by T(H)2 cells. NFIL3 is highly expressed in T(H)2 cells but much less in T(H)1 cells. Production of interleukin (IL)-13 and IL-5 is significantly increased in Nfil3(-/-) T(H)2 cells and is decreased by expression of NFIL3 in wild-type T(H)2 cells. NFIL3 directly binds to and negatively regulates the Il13 gene. In contrast, IL-4 production is decreased in Nfil3(-/-) T(H)2 cells. Increased IL-13 and IL-5 together with decreased IL-4 production by antigen-stimulated splenocytes from the immunized Nfil3(-/-) mice was also observed. The ability of NFIL3 to alter T(H)2 cytokine production is a T-cell intrinsic effect. Taken together, these data indicate that NFIL3 is a key regulator of T(H)2 responses. |
