Primary Identifier | MGI:4437472 | Allele Type | Targeted |
Gene | Cryaa | Transmission | Germline |
Strain of Origin | 129 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The codon for arginine 49 was altered to cysteine by homologous recombination. A loxP flanked neomycin cassette was introduced between exon 1 and 2. The reduction in protein expression was confirmed by chromatography profile (30% in lens from heterozygous mice). |