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Allele : Tg(Thy1-TARDBP)6Singh transgene insertion 6, Samir Kumar-Singh

Primary Identifier	MGI:4438491	Allele Type	Transgenic
Attribute String	Humanized sequence, Inserted expressed sequence	Gene	Tg(Thy1-TARDBP)6Singh
Strain of Origin	C57BL/6 and SJL	Is Recombinase	false
Is Wild Type	false

molecularNote

The cDNA of human TARDBP was driven by Thy1 promoter. Quantitative RT-PCR on brain tissue of 3 week old homozygous mice determined this line to have a 1.2 fold increase over endogenous gene expression.

mutations:
Insertion

synonyms:
TAR6,
TAR6

earliestPublication:
Wils H, et al. (2010) TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A 107(8):3858-63

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

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