Primary Identifier | MGI:4437845 | Allele Type | Chemically induced (ENU) |
Attribute String | Hypomorph | Gene | Rdh10 |
Inheritance Mode | Recessive | Strain of Origin | 129S1/Sv or C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | ENU mutagenesis induced a T to C transition at nucleotide 251 (NM_133832) that results in the amino acid substitution of arginine for cystinine. This mutation is predicted to disrupt the first beta strand of the protein. Residual Retinoic Acid signaling is detected in the trunk neural tube indicating this is a severely hypomorphic allele. |