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Allele : Tg(Thy1-APP)16Ppa transgene insertion 16, Paolo Paganetti

Primary Identifier	MGI:4438891	Allele Type	Transgenic
Attribute String	Inserted expressed sequence	Gene	Tg(Thy1-APP)16Ppa
Strain of Origin	C57BL/6J	Is Recombinase	false
Is Wild Type	false

molecularNote

A human APP751 cDNA was placed under the control of the murine Thy-1 minigene. This particular transgenic line expresses human APP at a level five or more fold greater than expression of the endogenous gene.

mutations:
Insertion

synonyms:
APP51/22,
Tg(Thy1-APP)51/16Npa,
Tg(Thy1-APP)51/16Npa,
APP51/22

earliestPublication:
Bodendorf U, et al. (2002) Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid. J Neurochem 80(5):799-806

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

13 Publication categories

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