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Allele : Lmnb2<tm1Ccof> lamin B2; targeted mutation 1, Catherine Coffinier

Primary Identifier	MGI:4440427	Allele Type	Targeted
Attribute String	Null/knockout, Reporter	Gene	Lmnb2
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

Exon 1 was replaced with an AUG-lacZ and floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on embryonic fibroblast extracts.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

earliestPublication:
Coffinier C, et al. (2010) Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A 107(11):5076-81

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

6 Publication categories

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