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Allele : Del(4C4-C5)1Lap deletion, Chr 4, Len A Pennacchio 1
Primary Identifier  MGI:4440552 Allele Type  Targeted
Attribute String  Null/knockout Gene  Del(4C4-C5)1Lap
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  Cre mediated recombination removed a floxed 70 kb region corresponding to the human 9p21 non-coding coronary artery disease risk interval. The 5' targeting vector contained a 5' homologous region and loxP site upstream of a neo cassette while the 3' targeting vector contained a copy of the 3' homologous region and hygro cassette upstream of a loxP site. Reduced expression of Cdkn2a and Cdkn2b was confirmed by qRT-PCR on heart and other tissue extracts.
  • mutations:
  • Intragenic deletion,
  • Insertion,
  • Intergenic deletion
  • synonyms:
  • ANRIL<->,
  • ANRIL<->,
  • chr4<delta70kb>,
  • chr4<delta70kb>,
  • Del1Lap,
  • Del1Lap
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1 Feature

Genome

0 Expresses

1 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

12 Publication categories





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