| Primary Identifier | MGI:4455060 | Allele Type | Chemically induced (ENU) |
| Gene | Fas | Inheritance Mode | Recessive |
| Strain of Origin | C57BL/6JAnu | Is Recombinase | false |
| Is Wild Type | false | Project Collection | APF ENU Mutagenesis |
| description | The mutation is a loss-of-function point mutation at the Fas gene that results in high titers of antinuclear Ab (ANA+) in the mice, as well as an accumulation of double-negative T cells in the periphery as the mice age; in these respects, they are very similar to the Faslpr/lpr mice strain (L. Tze and C. Goodnow, unpublished observations). |
| molecularNote | The mutation, in exon 4 of the gene (ENSMUSE00000144910), has been identified as a G to A transition at nucleotide position 422 of the cDNA sequence; it is predicted to result in replacement of cysteine by tyrosine at amino acid position 139 of the protein (C139Y). |
