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Allele : Pold1<tm1.1Bdp> polymerase (DNA directed), delta 1, catalytic subunit; targeted mutation 1.1, Bradley D Preston

Primary Identifier  MGI:4458032 Allele Type  Targeted
Attribute String  Not Specified Gene  Pold1
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A point mutation resulting in an aspartic acid to alanine substition at residue 400 (D400A) was introduced at the endogenous locus by homologous recombination of a targeting vector also carrying an intronic neo cassette. The neo cassette was removed by cre-mediated recombination. The missense mutation was introduced into sequence encoding the proofreading domain.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • Pold1<e>,
  • Pold1<e>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

5 Publication categories