| First Author | Enriquez-Algeciras M | Year | 2011 |
| Journal | Invest Ophthalmol Vis Sci | Volume | 52 |
| Issue | 5 | Pages | 2405-11 |
| PubMed ID | 21228378 | Mgi Jnum | J:171534 |
| Mgi Id | MGI:4950329 | Doi | 10.1167/iovs.10-6425 |
| Citation | Enriquez-Algeciras M, et al. (2011) Evaluation of a transgenic mouse model of multiple sclerosis with noninvasive methods. Invest Ophthalmol Vis Sci 52(5):2405-11 |
| abstractText | Purpose. To evaluate the ND4 transgenic mouse model of multiple sclerosis using noninvasive METHODS: Methods. Assessment of neurologic/behavioral abnormalities was made using pattern electroretinogram (PERG), magnetic resonance imaging (MRI), optic coherence tomography (OCT), and end point histologic analysis. Results. Electrophysiologic (PERG) recordings demonstrated functional deficits in vision commensurate with neurologic/behavioral abnormalities. In ND4 mice, the authors found PERG abnormalities preceded neurologic/gait abnormalities. MRI demonstrated subtle structural changes that progressed over time in correlation with behavioral abnormalities. Conclusions. The ND4 mouse model has been evaluated using well-defined parameters of noninvasive methods (PERG, MRI, and OCT), enabling objective identification of functional and structural deficits and their correlation with neurologic/gait abnormality. |
