| First Author | Cyktor JC | Year | 2013 |
| Journal | Infect Immun | Volume | 81 |
| Issue | 4 | Pages | 1090-9 |
| PubMed ID | 23340310 | Mgi Jnum | J:194060 |
| Mgi Id | MGI:5470206 | Doi | 10.1128/IAI.01199-12 |
| Citation | Cyktor JC, et al. (2013) Killer Cell Lectin-Like Receptor G1 Deficiency Significantly Enhances Survival after Mycobacterium tuberculosis Infection. Infect Immun 81(4):1090-9 |
| abstractText | The expression of T cell differentiation markers is known to increase during Mycobacterium tuberculosis infection, and yet the biological role of such markers remains unclear. We examined the requirement of the T cell differentiation marker killer cell lectin-like receptor G1 (KLRG1) during M. tuberculosis infection using mice deficient in KLRG1. KLRG1(-/-) mice had a significant survival extension after M. tuberculosis infection compared to wild-type controls, and maintained a significantly lower level of pulmonary M. tuberculosis throughout chronic infection. Improved control of M. tuberculosis infection was associated with an increased number of activated pulmonary CD4(+) T cells capable of secreting gamma interferon (IFN-gamma). Our report is the first to show an in vivo impact of KLRG1 on disease control. |
