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Allele : Lrrk2<tm2.1Shn> leucine-rich repeat kinase 2; targeted mutation 2.1, Jie Shen

Primary Identifier	MGI:4460960	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Lrrk2
Transmission	Germline	Strain of Origin	(C57BL/6 x 129)F1
Is Recombinase	false	Is Wild Type	false

molecularNote

The promoter region and exon 1 were replaced with a floxed neo cassette. Cre mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
Lrrk2<KO1>,
Lrrk2<KO1>

earliestPublication:
Tong Y, et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of {alpha}-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A 107(21):9879-84

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

9 Publication categories

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