| Primary Identifier | MGI:4461407 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Igh-7 |
| Transmission | Germline | Strain of Origin | C57BL/6 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | DNA sequence encoding the human M1' segment was inserted immediately following the splice acceptor site of the mouse IgE M1 exon. In addition, an IRES element followed by a GFP construct modified to encode an F64A amino acid change and then a floxed neomycin selection cassette were all inserted downstream of the mouse IgE M2 exon. The selection cassette was subsequently excised by transient in vitro cre expression. |
