Primary Identifier | MGI:4818431 | Allele Type | Targeted |
Attribute String | Recombinase | Gene | Hoxb8 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | true | Is Wild Type | false |
molecularNote | Exon 1 of Hoxb8 was replaced with cre fused to a mutated estrogen receptor followed by an FRT-flanked neo selection cassette. The neo was subsequently removed by breeding to FLPe deleter animals. In homozygous mice, the allele acts as a null allele for Hoxb8. |