Primary Identifier | MGI:4819105 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(Thy1-PSEN1*G384A)45Jckr |
Strain of Origin | Not Specified | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A human PSEN1 cDNA with a mutation in the codon for amino acid residue 384 causing a glycine to alanine change (G384A) was placed under the control of the murine Thy1.2 minigene. This mutant form is known to increase Abeta1-42 production. |