| Primary Identifier | MGI:4822481 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Adam17 |
| Transmission | Germline | Strain of Origin | 129S/SvEv |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An FRT flanked neo with a 5' loxP site was inserted upstream of exon 11. An artificial exon (11a) was created in intron 11 by inserting a cryptic splice donor site upstream of an existing cryptic acceptor site in intron 11. If spliced in, exon 11a creates a truncated CDS owing to an in-frame stop codon at the 5' end. A loxP site was inserted at the 3' end of exon 11a. |
