Primary Identifier | MGI:4830587 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(KRT14-Ptch1)#Abal |
Strain of Origin | FVB/N | Is Recombinase | false |
Is Wild Type | false |
molecularNote | An HA-tagged Ptch1 sequence from C57BL/6 was modified to encode the Threonine to Asparagine sustitution at amino acid residue 1267 which is found in FVB/N strains. Residue 1267 is found in a conserved region of the cytoplasmic domain near the C-terminus. The modified sequence was placed under the control of the human KRT14 promoter. At least four founder lines were produced (numbers 6, 7, 8, 10). |