| First Author | Le Noir S | Year | 2017 |
| Journal | Oncotarget | Volume | 8 |
| Issue | 8 | Pages | 12929-12940 |
| PubMed ID | 28088785 | Mgi Jnum | J:333379 |
| Mgi Id | MGI:6726720 | Doi | 10.18632/oncotarget.14585 |
| Citation | Le Noir S, et al. (2017) The IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection. Oncotarget 8(8):12929-12940 |
| abstractText | Immunoglobulin heavy chain (IgH) alleles have ambivalent relationships: they feature both allelic exclusion, ensuring monoallelic expression of a single immunoglobulin (Ig) allele, and frequent inter-allelic class-switch recombination (CSR) reassembling genes from both alleles. The IgH locus 3' regulatory region (3'RR) includes several transcriptional cis-enhancers promoting activation-induced cytidine deaminase (AID)-dependent somatic hypermutation (SHM) and CSR, and altogether behaves as a strong super-enhancer. It can also promote deregulated expression of translocated oncogenes during lymphomagenesis. Besides these rare, illegitimate and pathogenic interactions, we now show that under physiological conditions, the 3'RR super-enhancer supports not only legitimate cis- , but also trans-recruitment of AID, contributing to IgH inter-allelic proximity and enabling the super-enhancer on one allele to stimulate biallelic SHM and CSR. Such inter-allelic activating interactions define transvection, a phenomenon well-known in drosophila but rarely observed in mammalian cells, now appearing as a unique feature of the IgH 3'RR super-enhancer. |
