| First Author | Zhou D | Year | 2010 |
| Journal | Nat Genet | Volume | 42 |
| Issue | 9 | Pages | 742-4 |
| PubMed ID | 20676097 | Mgi Jnum | J:164803 |
| Mgi Id | MGI:4835346 | Doi | 10.1038/ng.637 |
| Citation | Zhou D, et al. (2010) KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching. Nat Genet 42(9):742-4 |
| abstractText | We show that knockdown of KLF1 in human and mouse adult erythroid progenitors markedly reduces BCL11A levels and increases human gamma-globin/beta-globin expression ratios. These results suggest that KLF1 controls globin gene switching by directly activating beta-globin and indirectly repressing gamma-globin gene expression. Controlled knockdown of KLF1 in adult erythroid progenitors may provide a method to activate fetal hemoglobin expression in individuals with beta-thalassemia or sickle cell disease. |
