| First Author | Gordon AR | Year | 2008 |
| Journal | J Biol Chem | Volume | 283 |
| Issue | 18 | Pages | 11897-904 |
| PubMed ID | 18285334 | Mgi Jnum | J:136545 |
| Mgi Id | MGI:3796470 | Doi | 10.1074/jbc.M709569200 |
| Citation | Gordon AR, et al. (2008) Splenomegaly and modified erythropoiesis in KLF13-/- mice. J Biol Chem 283(18):11897-904 |
| abstractText | To study the function of the Kruppel-like transcription factor KLF13 in vivo, we generated mice with a disrupted Klf13 allele. Although Klf13(-/-) mice are viable, fewer mice were present at 3 weeks than predicted by Mendelian inheritance. Viable Klf13(-/-) mice had reduced numbers of circulating erythrocytes and a larger spleen. The spleen contained an increased number of Ter119(med)CD71(hi), Ter119(hi)CD71(hi), and Ter119(hi)CD71(med) cells but not Ter119(hi)CD71(-) cells, indicating an increase in less mature erythroblasts. A higher proportion of the Ter119(med)CD71(hi) cells were proliferating, indicating that the mice were under a degree of erythropoietic stress. These data indicate that KLF13 is involved in the normal control of erythropoiesis. |
