| First Author | Toyama S | Year | 2021 |
| Journal | Int J Mol Sci | Volume | 22 |
| Issue | 14 | PubMed ID | 34299063 |
| Mgi Jnum | J:316123 | Mgi Id | MGI:6753425 |
| Doi | 10.3390/ijms22147443 | Citation | Toyama S, et al. (2021) Regulatory T Cells Exhibit Interleukin-33-Dependent Migratory Behavior during Skin Barrier Disruption. Int J Mol Sci 22(14) |
| abstractText | Regulatory T cells (Tregs) suppress immune responses and maintain immunological self-tolerance and homeostasis. We currently investigated relationships between skin barrier condition and Treg behavior using skin barrier-disrupted mice. Skin barrier disruption was induced by repeated topical application of 4% sodium dodecyl sulfate (SDS) on mice. The number of CD4(+) forkhead box protein P3 (Foxp3)(+) Tregs was higher in 4% SDS-treated skins than in controls. This increasing was correlated with the degree of acanthosis. The numbers of interleukin (IL)-10(+) and transforming growth factor (TGF)-beta(+) Tregs also increased in 4% SDS-treated skins. Localization of IL-33 in keratinocytes shifted from nucleus to cytoplasm after skin barrier disruption. Notably, IL-33 promoted the migration of Tregs in chemotaxis assay. The skin infiltration of Tregs was cancelled in IL-33 neutralizing antibody-treated mice and IL-33 knockout mice. Thus, keratinocyte-derived IL-33 may induce Treg migration into barrier-disrupted skin to control the phase transition between healthy and inflammatory conditions. |
