| First Author | Vo AV | Year | 2016 |
| Journal | Mol Immunol | Volume | 69 |
| Pages | 70-6 | PubMed ID | 26675069 |
| Mgi Jnum | J:234675 | Mgi Id | MGI:5790557 |
| Doi | 10.1016/j.molimm.2015.11.009 | Citation | Vo AV, et al. (2016) Expression of DNAM-1 (CD226) on inflammatory monocytes. Mol Immunol 69:70-6 |
| abstractText | DNAM-1 is an activating receptor expressed on NK cells and T cells and plays an important role in cytotoxicity of these cells against target cells. Although the role of DNAM-1 in the function of T cells and NK cells has been well studied, the expression and function of DNAM-1 on myeloid cells have been incompletely understood. In this study, we investigated expression of DNAM-1 on monocyte subsets in mouse peripheral blood and found that only inflammatory monocytes (iMos), but not patrolling monocytes (pMos), expressed high levels of DNAM-1. In addition, we found that DNAM-1 was highly expressed on iMos, rather than pMos, also in human. Furthermore, we found that DNAM-1 on inflammatory monocytes was involved in cell adhesion to CD155-expressing cells. Therefore, we propose that expression of DNAM-1 on inflammatory monocytes are evolutionally conserved and act as an adhesion molecule on blood inflammatory monocytes. |
