| First Author | Zhang K | Year | 2022 |
| Journal | Cell Rep | Volume | 38 |
| Issue | 4 | Pages | 110289 |
| PubMed ID | 35081355 | Mgi Jnum | J:324793 |
| Mgi Id | MGI:6874532 | Doi | 10.1016/j.celrep.2021.110289 |
| Citation | Zhang K, et al. (2022) The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I. Cell Rep 38(4):110289 |
| abstractText | The meiosis-specific telomere-binding protein TERB1 anchors telomeres to the nuclear envelope and drives chromosome movements for the pairing of homologous chromosomes. TERB1 has an MYB-like DNA-binding (MYB) domain, which is a hallmark of telomeric DNA-binding proteins. Here, we demonstrate that the TERB1 MYB domain has lost its canonical DNA-binding activity. The analysis of Terb1 point mutant mice expressing TERB1 lacking its MYB domain showed that the MYB domain is dispensable for telomere localization of TERB1 and the downstream TERB2-MAJIN complex, the promotion of homologous pairing, and even fertility. Instead, the TERB1 MYB domain regulates the enrichment of cohesin and promotes the remodeling of axial elements in the early-to-late pachytene transition, which suppresses telomere erosion. Considering its conservation across metazoan phyla, the TERB1 MYB domain is likely to be important for the maintenance of telomeric DNA and thus for genomic integrity by suppressing meiotic telomere erosion over long evolutionary timescales. |
