| First Author | Ch'ng SS | Year | 2015 |
| Journal | J Chem Neuroanat | Volume | 66-67 |
| Pages | 1-9 | PubMed ID | 25841630 |
| Mgi Jnum | J:256544 | Mgi Id | MGI:6114421 |
| Doi | 10.1016/j.jchemneu.2015.03.002 | Citation | Ch'ng SS, et al. (2015) Distribution of the orexin-1 receptor (OX1R) in the mouse forebrain and rostral brainstem: A characterisation of OX1R-eGFP mice. J Chem Neuroanat 66-67:1-9 |
| abstractText | We have utilised a transgenic reporter mouse in which green fluorescent protein (GFP) expression is driven by the orexin-1 receptor (OX1R) promoter to systematically map the distribution of OX1R-expressing neurons throughout the mouse forebrain and rostral brainstem. GFP labelling was observed in perikarya and fibres in an extensive range of brain loci encompassing the olfactory and cerebral cortices, dorsal and ventral pallidum, hippocampus, amygdaloid regions, septal areas, thalamic nuclei, hypothalamic nuclei and several brainstem regions, consistent with previous studies of OX1R mRNA expression. This is the first study to systematically characterise the neuroanatomical distribution of OX1R in the OX1R-eGFP mouse, confirming its veracity as a faithful reporter of OX1R expression and utility for future studies assessing the role of OX1R in more complex behaviours. |
