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Allele : Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo transgene insertion 110, David R Borchelt
Primary Identifier  MGI:4849838 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo
Strain of Origin  (C57BL/6 x C3H)F2 Is Recombinase  false
Is Wild Type  false
molecularNote  The mouse promoter drives neuronal expression of human SOD1 containing the G37R mutation found in patients with familial amyotrophic lateral sclerosis. This transgene was co-injected with Tg(PSEN1)S8-4Dbo. Two lines were generated (39 and 110).
  • mutations:
  • Insertion
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1 Feature

Genome

2 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Carried By

0 Driven By

6 Publication categories





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