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Allele : Csf2/Il3<tm1.1(CSF2,IL3)Flv> colony stimulating factor 2 (granulocyte-macrophage); targeted mutation 1.1, Richard A Flavell

Primary Identifier	MGI:4887879	Allele Type	Targeted
Attribute String	Humanized sequence, Inserted expressed sequence	Gene	Csf2
Transmission	Germline	Strain of Origin	BALB/cAnNTac x 129S4/SvJae
Is Recombinase	false	Is Wild Type	false

description	Originally generated in ES cells containing Il2rg^tm1.1Flv and Rag2^tm1.1Flv.
molecularNote	The coding region of Il3 through Csf2 was replaced with the corresponding human sequence. The human Il3 remains under the control of the mouse promoter while expression of Csf2 is controlled by the human promoter. Cre-mediated recombination removed the selection cassettes.

mutations:
Intergenic deletion,
Insertion

cellLines:
Not Specified

earliestPublication:
Willinger T, et al. (2011) Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proc Natl Acad Sci U S A 108(6):2390-5

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

3 Carried By

0 Driven By

21 Publication categories

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