| First Author | Kim HJ | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 14 | Pages | 2285-90 |
| PubMed ID | 21679708 | Mgi Jnum | J:174214 |
| Mgi Id | MGI:5052210 | Doi | 10.1016/j.febslet.2011.05.057 |
| Citation | Kim HJ, et al. (2011) HVEM-deficient mice fed a high-fat diet are protected from adipose tissue inflammation and glucose intolerance. FEBS Lett 585(14):2285-90 |
| abstractText | HVEM is a member of the TNF receptor superfamily that plays a role in the development of various inflammatory diseases. In this study, we show that HVEM deficiency attenuates adipose tissue inflammatory responses and glucose intolerance in diet-induced obesity. Feeding a high-fat diet (HFD) to HVEM-deficient mice elicited a reduction in the number of macrophages and T cells infiltrated into adipose tissue. Proinflammatory cytokine levels in the adipose tissue decreased in HFD-fed HVEM-deficient mice, while levels of the anti-inflammatory cytokine IL-10 increased. Moreover, glucose intolerance and insulin sensitivity were markedly improved in the HFD-fed HVEM-deficient mice. These findings indicate that HVEM may be a useful target for combating obesity-induced inflammatory responses and insulin resistance. |
