Primary Identifier | MGI:4941211 | Allele Type | Targeted |
Attribute String | Hypomorph, Inducible, Inserted expressed sequence, Reporter | Gene | Bmp4 |
Transmission | Germline | Strain of Origin | 129S4/SvJaeSor |
Induced With | doxycycline/tetracycline | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The insertion of a construct consisting of a tetracycline operator, CMV promoter, Bmp4 cDNA, IRES lacZ, and FRT flanked pgk-neo cassette, and a poly-adenylation sequence was inserted in place of a 665 bp region that includes the basal promoter and exon1 of the gene. Analysis of p-Smad1/5/8 activity in heterozygous mice indicates this is a hypomorphic allele. |