| First Author | Aoto J | Year | 2015 |
| Journal | Nat Neurosci | Volume | 18 |
| Issue | 7 | Pages | 997-1007 |
| PubMed ID | 26030848 | Mgi Jnum | J:224471 |
| Mgi Id | MGI:5662329 | Doi | 10.1038/nn.4037 |
| Citation | Aoto J, et al. (2015) Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses. Nat Neurosci 18(7):997-1007 |
| abstractText | alpha- and beta-neurexins are presynaptic cell-adhesion molecules whose general importance for synaptic transmission is well documented. The specific functions of neurexins, however, remain largely unknown because no conditional neurexin knockouts are available and targeting all alpha- and beta-neurexins produced by a particular gene is challenging. Using newly generated constitutive and conditional knockout mice that target all neurexin-3alpha and neurexin-3beta isoforms, we found that neurexin-3 was differentially required for distinct synaptic functions in different brain regions. Specifically, we found that, in cultured neurons and acute slices of the hippocampus, extracellular sequences of presynaptic neurexin-3 mediated trans-synaptic regulation of postsynaptic AMPA receptors. In cultured neurons and acute slices of the olfactory bulb, however, intracellular sequences of presynaptic neurexin-3 were selectively required for GABA release. Thus, our data indicate that neurexin-3 performs distinct essential pre- or postsynaptic functions in different brain regions by distinct mechanisms. |
