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Allele : Tg(Ins2-Hnf1a)#Cbw transgene insertion, Claes B Wollheim

Primary Identifier	MGI:4942165	Allele Type	Transgenic
Attribute String	Dominant negative, Inserted expressed sequence	Gene	Tg(Ins2-Hnf1a)#Cbw
Strain of Origin	(C57BL/6 x CBA/J)F2	Is Recombinase	false
Is Wild Type	false

molecularNote

The rat promoter drives beta cell expression of a cDNA for a dominant negative product that lacks 83 amino acids in the DNA-binding domain.

mutations:
Insertion

synonyms:
RIP-DNHNF1alpha,
RIP-DNHNF1alpha

earliestPublication:
Hagenfeldt-Johansson KA, et al. (2001) Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice. Endocrinology 142(12):5311-20

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

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