| First Author | Arrant AE | Year | 2015 |
| Journal | eNeuro | Volume | 2 |
| Issue | 3 | PubMed ID | 26361634 |
| Mgi Jnum | J:229416 | Mgi Id | MGI:5751946 |
| Doi | 10.1523/ENEURO.0061-14.2015 | Citation | Arrant AE, et al. (2015) Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice. eNeuro 2(3) |
| abstractText | Loss-of-function mutations in progranulin (GRN) are one of the most common genetic causes of frontotemporal dementia (FTD), a progressive, fatal neurodegenerative disorder with no available disease-modifying treatments. Through haploinsufficiency, these mutations reduce levels of progranulin, a protein that has neurotrophic and anti-inflammatory effects. Increasing progranulin expression from the intact allele is therefore a potential approach for treating individuals with GRN mutations. Based on the well-known effects of physical exercise on other neurotrophic factors, we hypothesized that exercise might increase brain progranulin levels. We tested this hypothesis in progranulin heterozygous (Grn + / -) mice, which model progranulin haploinsufficiency. We housed wild-type and progranulin-insufficient mice in standard cages or cages with exercise wheels for 4 or 7.5 weeks, and then measured brain and plasma progranulin levels. Although exercise modestly increased progranulin in very young (2-month-old) wild-type mice, this effect was limited to the hippocampus. Exercise did not increase brain progranulin mRNA or protein in multiple regions, nor did it increase plasma progranulin, in 4- to 8-month-old wild-type or Grn + / |
