| First Author | Hintze A | Year | 2024 |
| Journal | iScience | Volume | 27 |
| Issue | 1 | Pages | 108700 |
| PubMed ID | 38213623 | Mgi Jnum | J:346015 |
| Mgi Id | MGI:7573728 | Doi | 10.1016/j.isci.2023.108700 |
| Citation | Hintze A, et al. (2024) Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus. iScience 27(1):108700 |
| abstractText | Mitochondria are key organelles to provide ATP for synaptic transmission. This study aims to unravel the structural adaptation of mitochondria to an increase in presynaptic energy demand and upon the functional impairment of the auditory system. We use the anteroventral cochlear nucleus (AVCN) of wild-type and congenital deaf mice before and after hearing onset as a model system for presynaptic states of lower and higher energy demands. We combine focused ion beam scanning electron microscopy and electron tomography to investigate mitochondrial morphology. We found a larger volume of synaptic boutons and mitochondria after hearing onset with a higher crista membrane density. In deaf animals lacking otoferlin, we observed a shallow increase of mitochondrial volumes toward adulthood in endbulbs, while in wild-type animals mitochondria further enlarged. We propose that in the AVCN, presynaptic mitochondria undergo major structural changes likely to serve higher energy demands upon the onset of hearing and further maturation. |
