| Primary Identifier | MGI:4950563 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Prpf8 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An FRT neo cassette was inserted into intron 42 and an A to C mutation resulting in a histidine to proline substitution at position 2309 (H2309P) was introduced in exon 42 via homologous recombination. Flp mediated recombination removed the neo cassette. Northern blot analysis indicates the transcript size and level of transcript expression in retinas from homozygous mice are similar to wild-type controls. |
