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Allele : Tg(tetO-TARDBP)12Vle transgene insertion 12, Virginia M Y Lee

Primary Identifier	MGI:5000260	Allele Type	Transgenic
Attribute String	Humanized sequence, Inducible, Inserted expressed sequence	Gene	Tg(tetO-TARDBP)12Vle
Strain of Origin	(C57BL/6J x C3H/HeJ)F1	Induced With	doxycycline/tetracycline
Is Recombinase	false	Is Wild Type	false

molecularNote

The tetracycline responsive promoter drives inducible expression of the wild-type human cDNA. Four lines were generated (4, 5, 8, and 12).

mutations:
Insertion

synonyms:
hTDP-43-WT12,
hTDP-43-WT12

earliestPublication:
Igaz LM, et al. (2011) Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest 121(2):726-38

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

9 Publication categories

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