| Primary Identifier | MGI:5006688 | Allele Type | Targeted |
| Gene | Fasl | Transmission | Germline |
| Strain of Origin | 129 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Nucleotide substitution within exon 2 resulted in the amino acid substitution of threonine for serine at position 124 (S124T), phenylalanine for leucine at position 125 (L125F), arginine for lysine at position 127 (L127R), and glutamine for asparagine at position 128 (N128Q). These mutations prevent cleavage of the protein to produce the soluble form. The floxed neo cassette used for selection was removed by cre-mediated recombination. |
