| Primary Identifier | MGI:5006860 | Allele Type | Transgenic |
| Attribute String | Reporter | Gene | Tg(Mov1/Tyr)OVE876BPay |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Sequences from the 5' end of the Moloney murine leukemia virus were linked to a tyrosinase minigene consisting of a 2.1-kb promoter linked to a 1.9-kb tyrosinase cDNA. Expression of the tyrosinase minigene leads to melanin synthesis in the skin and fur. The transgene inserted in the non-coding region between Gm732 and Brwd3 on chromosome X. PCR amplification with minigene-only primer sets suggests that at minimum 2 copies inserted in tandem, while Southern blot hybridization indicates a maximum of 4 copies inserted together. Expression of Fam46d, located near the site of transgenic intergration, is upregulated. |
