| First Author | Nguyen TA | Year | 2017 |
| Journal | Immunity | Volume | 47 |
| Issue | 3 | Pages | 498-509.e6 |
| PubMed ID | 28916264 | Mgi Jnum | J:256177 |
| Mgi Id | MGI:6114485 | Doi | 10.1016/j.immuni.2017.08.007 |
| Citation | Nguyen TA, et al. (2017) SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition. Immunity 47(3):498-509.e6 |
| abstractText | Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal evolution, but the physiological role of SID-1 and its orthologs remains unclear. Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation. Sidt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes simplex virus 1 (HSV-1) show impaired production of antiviral cytokines and-in the case of EMCV and HSV-1-reduced survival. Thus, SIDT2 has retained the dsRNA transport activity of its C. elegans ortholog, and this transport is important for antiviral immunity. |
