Primary Identifier | MGI:5009236 | Allele Type | Targeted |
Attribute String | Recombinase | Gene | Notch1 |
Transmission | Germline | Strain of Origin | 129X1/SvJ |
Is Recombinase | true | Is Wild Type | false |
molecularNote | The Notch1 intracellular domain (IC) is replaced by the cre recombinase sequence and includes the SV40 3' UTR polyA signal while introducing a single nucleotide variation (SNV) at C5178A to facilitate genotyping. This allele does not have the 6xMyc tag present in the Notch1tm3(cre)Rko allele, and displays enhanced activity relative to that allele. |