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Allele : Tg(Klk8-tTA)SMmay transgene insertion S, Mark Mayford
Primary Identifier  MGI:5014077 Allele Type  Transgenic
Attribute String  Transactivator Gene  Tg(Klk8-tTA)SMmay
Strain of Origin  (C57BL/6 x DBA)F2 Is Recombinase  false
Is Wild Type  false Project Collection  Neuroscience Blueprint cre
molecularNote  An ~120 kb mouse bacterial artificial chromosome (BAC) containing the entire mouse kallikrein related-peptidase 8 (Klk8; also called Prss19 or neuropsin) locus, and ~50 kb of upstream and ~70 kb of downstream sequences, was modified by targeting a human codon-optimized tetracycline-regulated transactivator gene (tTA or htTA or "Tet-Off") into the first exon upstream of the Prss19 translation initiation site. The resulting modified BAC was microinjected into (C57BL/6;DBA)F2 embryos. Founder mice were bred to C57BL/6J inbred mice to establish founder line S.
  • mutations:
  • Insertion
  • synonyms:
  • Nop-tTA,
  • tTA-EC,
  • Prss19-tTA1,
  • Neuropsin-htTa,
  • TgEC-tTA,
  • tTA-EC,
  • Prss19-tTA line 1,
  • Neuropsin-htTa,
  • TgEC-tTA,
  • Prss19-tTA1,
  • Nop-tTA,
  • Prss19-tTA line 1
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

19 Publication categories





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