Primary Identifier | MGI:5052118 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Eno2-PSEN2*)1480Ykk |
Strain of Origin | (C57BL/6 x DBA/2)F2 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A 1.8kb fragment of the rat Eno2 promoter drives expression of a human PSEN2 cDNA with an N141I mutation found in Volga German families. The highest levels of transgene mRNA expression were detected in the anterior brain, followed by posterior brain, muscle, lung, heart, and liver. |