| First Author | Stewart MH | Year | 2014 |
| Journal | Blood | Volume | 124 |
| Issue | 20 | Pages | 3076-80 |
| PubMed ID | 25274507 | Mgi Jnum | J:218676 |
| Mgi Id | MGI:5618186 | Doi | 10.1182/blood-2014-05-575308 |
| Citation | Stewart MH, et al. (2014) Growth hormone receptor signaling is dispensable for HSC function and aging. Blood 124(20):3076-80 |
| abstractText | Growth hormone receptor (Ghr) signaling is important in a wide variety of cellular processes including aging; however, the role of Ghr signaling in hematopoietic stem cell (HSC) biology remains unexplored. Within the hematopoietic system, Ghr is expressed in a highly HSC-specific manner and is significantly upregulated during aging. Exposure of young and old HSCs to recombinant growth hormone ex vivo led to diminished short-term reconstitution and restored B-cell output from old HSCs. Hematopoietic-specific genetic deletion of Ghr neither impacted steady-state hematopoiesis nor serial transplantation potential. Repeat challenge with 5-fluorouracil showed that Ghr was dispensable for HSC activation and homeostatic recovery in vivo and, after challenge, Ghr-deficient HSCs functioned normally through serial transplantation. Although exogenous Gh induces age-dependent HSC effects, these results indicate that Ghr signaling appears largely dispensable for HSC function and aging. |
