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Allele : Sqstm1<tm1.1Sral> sequestosome 1; targeted mutation 1.1, Stuart H Ralston
Primary Identifier  MGI:5056451 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Sqstm1
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 8 was replaced with a modified exon with a C to T transition that results in the amino acid substitution of leucine for proline at position 394 (P394L), mimicking a mutation found in some Paget's disease of bone (PDB) patients. Cre-mediated recombination removed the neo cassette inserted upstream of the modified exon 8.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • P394L<+>,
  • P394L<+>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories





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