| First Author | Matsumoto I | Year | 2011 |
| Journal | Nat Neurosci | Volume | 14 |
| Issue | 6 | Pages | 685-7 |
| PubMed ID | 21572433 | Mgi Jnum | J:173905 |
| Mgi Id | MGI:5050544 | Doi | 10.1038/nn.2820 |
| Citation | Matsumoto I, et al. (2011) Skn-1a (Pou2f3) specifies taste receptor cell lineage. Nat Neurosci 14(6):685-7 |
| abstractText | Functional diversification of taste cells is crucial for proper discrimination of taste qualities. We found the homeodomain protein Skn-1a (Pou2f3) to be expressed in sweet, umami and bitter taste cells. Skn-1a-deficient mice lacked electrophysiological and behavioral responses to sweet, umami and bitter tastes, as a result of a complete absence of sweet, umami and bitter cells and the concomitant expansion of sour cells. Skn-1a is critical for generating and balancing the diverse composition of taste cells. |
