| Primary Identifier | MGI:5140116 | Allele Type | Targeted |
| Gene | Gjc2 | Transmission | Germline |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The coding region was replaced with a mutated version with a T to C exchange at nucleotide 845 (coding for a methionine to threonine transition at codon 282), and an IRES, lacZ gene with a nuclear localization signal and FRT flanked neo cassette were inserted via homologous recombination. Flp mediated recombination removed the neo cassette. LacZ expression coincides with endogenous gene expression. Homozygous and heterozygous mice show a reduction in GJC2 positive puncta in the brain and the mutant protein lacks the typical gap junctional immunosignals at oligodendrocytic somata. |
