| Help | About | Contact Us

Allele : Tet2<tm1.1Iaai> tet methylcytosine dioxygenase 2; targeted mutation 1.1, Iannis Aifantis

Primary Identifier	MGI:5141120	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Tet2
Transmission	Germline	Strain of Origin	(C57BL/6 x 129S/SvEv)F1
Is Recombinase	false	Is Wild Type	false

molecularNote

An FRT- and loxP-flanked neo cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exon 3 floxed.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
Tet2<f>,
Tet2<f>

earliestPublication:
Moran-Crusio K, et al. (2011) Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 20(1):11-24

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

94 Publication categories

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/report.do?id=76030393

MouseMine