| Primary Identifier | MGI:5292236 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Psen1 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 8 was replaced with a neo cassette and a modified exon 8 in which a G to T mutation results in the amino acid substitution of isoleucine for arginine at position 278 (R278I), mimicking a mutation found in a pedigree bearing atypical Alzheimer's disease with language impairment. Cre-mediated recombination removed the neo cassette. |
