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Allele : Psen1<tm1.1Tcs> presenilin 1; targeted mutation 1.1, Takaomi C Saido
Primary Identifier  MGI:5292236 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Psen1
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 8 was replaced with a neo cassette and a modified exon 8 in which a G to T mutation results in the amino acid substitution of isoleucine for arginine at position 278 (R278I), mimicking a mutation found in a pedigree bearing atypical Alzheimer's disease with language impairment. Cre-mediated recombination removed the neo cassette.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • PS1-R278I,
  • PS1-R278I
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Driven By

5 Publication categories

Trail: Allele




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